Intracellular interaction between sigma-1 and GABA-B receptors

We were happy to host the postdoctoral research of Dr. Edijs Vavers who has now summarized the results of his interesting project. Using innovative molecular biology and advanced microscopy techniques, the project successfully demonstrated intracellular interaction between the sigma-1 chaperone protein (SCP) and the GABA-B receptor. One of the most intriguing findings was the confirmation of the presence of SCP on extracellular vesicles. 

Dr. Edijs Vavers at the 4th European Symposium “Physiopathology of Sigma-1 Receptors”, Montpellier, France. Photo by Edijs Vavers.

This discovery opens exciting opportunities for further research into the role of SCP in intercellular communication and its potential therapeutic applications, paving the way for collaborative projects across neuroscience, molecular biology, and drug development. The project No. SJD34 “Intracellular interaction between sigma-1 chaperone and metabotropic gamma-amminobutyric acid receptors” (2022-2024) was funded by the Estonian Research Council and lead by incoming postdoctoral researcher Dr. Edijs Vavers (supervisors Prof. Ago Rinken and Dr. Sergei Kopanchuk).

Image created by Edijs Vavers. For more detailed information about the project contact [email protected].